INTEGRATIVE ANALYSIS OF FUNCTIONAL GENOMIC ANNOTATIONS AND SEQUENCING DATA TO IDENTIFY RARE CAUSAL VARIANTS VIA HIERARCHICAL MODELING

Integrative analysis of functional genomic annotations and sequencing data to identify rare causal variants via hierarchical modeling

Identifying the small number of rare causal variants contributing to disease has beena major focus of investigation in recent Pipe Accessory years, but represents a formidable statisticalchallenge due to the rare frequencies with which these variants are observed.In thiscommentary we draw attention to a formal statistical framework, namely hierarch

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Latest Evidence-Based Application for Radiofrequency Neurotomy (LEARN): Best Practice Guidelines from the American Society of Pain and Neuroscience (ASPN)

David W Lee,1 Scott Pritzlaff,2,3 Michael J Jung,2,3 Priyanka Ghosh,4 Jonathan M Hagedorn,5 Jordan Tate,6 Keith Scarfo,7 Natalie Strand,8 Krishnan Chakravarthy,9,10 Dawood Sayed,11 Timothy R Deer,12 Kasra Amirdelfan13 1Fullerton Orthopedic Surgery Medical Group, Fullerton, CA, 92831, USA; 2University of California, Davis; 3Division of Pain Medicine

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Numerical Simulation of the Nonlinear Fractional Dynamical Systems with Fractional Damping for the Extensible and Inextensible Pendulum

In this paper we consider a class of nonlinear dynamical systems with fractional damping.The problem is transformed into a system of fractional-order differential equations.A computationally effective fractional predictor-corrector 5 Piece Counter Height Dining Set method is used to simulate and examine the effects and solution behavior of the nonl

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Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches

Zearalenone (ZEA), a secondary metabolite of Fusarium fungi found in cereal-based foods, promotes the growth of colon, breast, and prostate cancer cells in vitro.However, the lack of animal studies hinders a deeper mechanistic understanding of the cancer-promoting effects of ZEA.This study aimed to determine the effect of ZEA on colon Rubber Soothe

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